communicate that is available to determine the AGP: alpha-1-acid glycoprotein specific cat is an individual and as a test profile that FIP \u200b\u200bis composed of:
- haemogram full
- AGP
-
Total Bilirubin - Total Protein
- Capillary electrophoresis of serum proteins
- Title Ac. FCoV / FIP IF
The examination is only performed on serum or weekly or biweekly basis depending on tests to perform.
The kit is used and validated by the recent international work.
The a1-acid glycoprotein (AGP) is a heavily glycosylated protein, and its pattern of glycosylation appears to be associated, in humans, resistance or susceptibility to infectious diseases. In cats the AGP is an acute phase protein "major", and increases in particular in the course of FIP, which reaches blood levels higher than those detected in the course of other diseases, so that to have diagnostic. In several publications Paltrinieri Professor (Faculty of Veterinary Medicine of Milan) and his collaborators have shown how one can record increases in blood concentration dell'AGP in cats infected with FCoV but asymptomatic, and as such increases occur in correspondence cases of FIP the group in which they live healthy animals examined. However, these increases remain below the range considered suggestive of FIP. This increase was also noted in a recent work, in which it was noted that fluctuations dell'AGP are associated with changes in antibody titers before and stages in the reduction in viral load. This could indicate that the AGP in the cat plays a protective role against viral diseases, possibly related to changes in its glycosylation. The degree of sialylated is in fact result in reduced only symptomatic but not in cats FCoV-positive non-symptomatic.
The AGP is therefore an acute phase protein that is useful in distinguishing FIP from other simili situazioni cliniche.
Bisogna tener presente, tuttavia, che la AGP non è specifica e quindi può risultare più elevata anche se c'è un'infezione virale non da FCoV, batterica (per es., colangioepatite o pielonefrite in fase ascendente) o infezioni da funghi o per un trauma recente. La misurazione dell’AGP è utile per distinguere la PIF da una neoplasia o da una malattia al fegato non infettiva, quando i livelli di AGP saranno normali.
Dr Emanuele Minetti
BiEsseA srl Milano
www.biessea.com
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